CD24+/CD38- as new prognostic marker for non-small cell lung

Background Lung cancer is the leading cause of death among cancers in the world. The annual death toll due to this disease exceeds the combined deaths caused by colon, breast, prostate, and pancreatic cancers. As a result, there has been a tremendous effort to identify new biomarkers for early detection and diagnosis of lung cancer. Methods In this study we report the results of screening a panel of eight non-small cell lung cancer (NSCLC) cell lines originating from different subtypes of lung cancer in an attempt to identify potential biomarkers unique to this disease. We used real-time polymerase chain reaction and flow cytometry techniques to analyze the expression of ALDHA1, EpCAM, CD133, CD24, and CD38 in this panel. Results We demonstrate for the first time that the majority of NSCLC cells do not express levels of CD38 that would qualify it as a new biomarker for the disease. In contrast, we found that CD24 is over-expressed in 6 out of 8 of the cell lines. The combined CD24+/CD38-/low phenotype was detected in 50% of the cell lines that are also positive for CD133 and EpCAM. Conclusions We report that CD24+/CD38-/low signature could potentially be used as a new biomarker for the early detection of NSCLC.

CD133+ circulating haematopoietic progenitor cells predict for

Inflammation and tumor progression: signaling pathways and

Defining lung cancer stem cells exosomal payload of miRNAs in

Stem Cells: Therapeutic Implications in Chemotherapy and

CD24 is an independent prognostic marker of survival in nonsmall

Vaccines, Free Full-Text

Defining lung cancer stem cells exosomal payload of miRNAs in

PDF) CD24+/CD38- As new prognostic marker for non-small cell lung

PDF) Sylvie Crogiez-Pétrequin (dir.), Dieu (x) et hommes. Histoire

Frontiers Tumor Immune Microenvironment Characteristics and

Nicotine inhibits CD24 expression in Lewis lung carcinoma cells by

Revised International Staging System (R-ISS) stage-dependent

PDF) Правна уредба на ограничителната заповед по българското

On Breasts, Bras, and Why I Hate Victoria's Secret (Part 2)

Alana Hairdressing

Love Ayu Font, Webfont & Desktop

Best Offers at The Glorious Restaurant in Adajan Dn, Surat - Justdial

Bank of Namibia - PART B: State Of The Economy - Macroeconomic Review